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PT-141

Libido, sexual function

FDA-approved (Vyleesi) for low sex drive. Works in the brain, not blood vessels — different from Viagra.

In Plain English

Viagra works on plumbing. PT-141 works on desire. Activates arousal centers in your brain. Works for both men and women.

A / B

At a glance

Works on desire in the brain. Nausea is the price. Evidence grade A / B on an A-to-D scale.

HOW IT IS TAKEN
Under the skin, 45 minutes or more before
HOW OFTEN
As needed; max 8 a month on the label
HOW LONG
Single doses
TESTED SPORT
Not banned

Reported practice from trials and the community, not a recommendation for anyone.

What Researchers Have Studied It For

+Brain-based arousal
+Works for men and women
+FDA-approved for HSDD
+Different from Viagra
+Melanocortin pathway
Molecular Weight
1025 Da
Half-Life
~2 hours
Source
Cyclic 7 amino acid peptide
Storage
Keep frozen as powder. Refrigerate once mixed.
Category
Sexual Health

Published Research

Bremelanotide for HSDD
Obstet Gynecol (2019)

Common questions about PT-141

What is PT-141 used for?

Researchers have studied PT-141 for brain-based arousal, works for men and women, fda-approved for hsdd, and more. In plain terms: Viagra works on plumbing. PT-141 works on desire. Activates arousal centers in your brain. Works for both men and women.

Is PT-141 FDA-approved?

Yes, as Vyleesi, for low sexual desire in premenopausal women. Use in men is off-label.

How is PT-141 usually taken?

The commonly reported pattern is under the skin, 45 minutes or more before, as needed; max 8 a month on the label, for single doses. That describes reported practice from trials and the community. It is not a recommendation for anyone, and several of these compounds interact with common medications.

How strong is the evidence for PT-141?

Grade A / B on this site's A-to-D scale. A means approved as a medicine somewhere, with large controlled trials behind that use. Works on desire in the brain. Nausea is the price.

Is PT-141 banned in drug-tested sport?

It is not specifically listed by the World Anti-Doping Agency, but tested athletes should check the current list and their federation's rules, since related compounds and blends often are.

How long does PT-141 stay in the body?

The half-life, the time for half a dose to leave the body, is about ~2 hours. A short half-life means it wears off fast and is taken more often; a long one means once a week can be enough. Stored as a dry powder it keeps for months in the fridge; once mixed with water it is used within a few weeks.

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Go deeper on PT-141 in The Peptide Course
How people commonly use it, what they notice, side effects, who stays away, and how good the evidence really is. Plus how to buy a vial that is actually PT-141, and how to mix it. Six lessons are free.
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Research-use disclaimer — PT-141 is referenced here for research education only. It is not approved by the FDA for human consumption, treatment, cure, or diagnosis of any condition. Nothing on this page is medical advice. Consult a licensed physician for anything related to your health.