Sermorelin
GH decline, sleep qualityThe OG of GH peptides. Originally FDA-approved in 1997 (Geref), later withdrawn from US market for commercial reasons — still available via compounding pharmacies.
In Plain English
The GH peptide with the longest clinical history. Used for decades in research and hormone clinics. Less potent than newer options but the most data behind it.
At a glance
The one with a prescription route. Weakest per dose. Evidence grade A / B on an A-to-D scale.
Reported practice from trials and the community, not a recommendation for anyone.
What Researchers Have Studied It For
Studied for
Published Research
Common questions about Sermorelin
What is Sermorelin used for?
Researchers have studied Sermorelin for longest clinical history, natural gh stimulation, deep sleep, and more. In plain terms: The GH peptide with the longest clinical history. Used for decades in research and hormone clinics. Less potent than newer options but the most data behind it.
Is Sermorelin FDA-approved?
It was, in 1997, for children who do not make enough growth hormone, and was later withdrawn for business reasons rather than safety. Compounding pharmacies can still supply it with a prescription.
How is Sermorelin usually taken?
The commonly reported pattern is under the skin at bedtime, nightly, for months. That describes reported practice from trials and the community. It is not a recommendation for anyone, and several of these compounds interact with common medications.
How strong is the evidence for Sermorelin?
Grade A / B on this site's A-to-D scale. A means approved as a medicine somewhere, with large controlled trials behind that use. The one with a prescription route. Weakest per dose.
Is Sermorelin banned in drug-tested sport?
Yes. Sermorelin is on the World Anti-Doping Agency prohibited list. Anyone who competes in a sport with drug testing, from college athletics to fitness competitions, can fail a test for it.
How long does Sermorelin stay in the body?
The half-life, the time for half a dose to leave the body, is about ~10–20 minutes. A short half-life means it wears off fast and is taken more often; a long one means once a week can be enough. Stored as a dry powder it keeps for months in the fridge; once mixed with water it is used within a few weeks.
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