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Sermorelin

GH decline, sleep quality

The OG of GH peptides. Originally FDA-approved in 1997 (Geref), later withdrawn from US market for commercial reasons — still available via compounding pharmacies.

In Plain English

The GH peptide with the longest clinical history. Used for decades in research and hormone clinics. Less potent than newer options but the most data behind it.

A / B

At a glance

The one with a prescription route. Weakest per dose. Evidence grade A / B on an A-to-D scale.

HOW IT IS TAKEN
Under the skin at bedtime
HOW OFTEN
Nightly
HOW LONG
Months
TESTED SPORT
Banned

Reported practice from trials and the community, not a recommendation for anyone.

What Researchers Have Studied It For

+Longest clinical history
+Natural GH stimulation
+Deep sleep
+Age-related GH decline
+Lean body mass
Molecular Weight
3358 Da
Half-Life
~10–20 minutes
Source
First 29 amino acids of GHRH
Storage
Keep frozen as powder. Refrigerate once mixed.
Category
Growth Hormone

Published Research

Sermorelin for adult GH insufficiency
Clin Interv Aging (2012)

Common questions about Sermorelin

What is Sermorelin used for?

Researchers have studied Sermorelin for longest clinical history, natural gh stimulation, deep sleep, and more. In plain terms: The GH peptide with the longest clinical history. Used for decades in research and hormone clinics. Less potent than newer options but the most data behind it.

Is Sermorelin FDA-approved?

It was, in 1997, for children who do not make enough growth hormone, and was later withdrawn for business reasons rather than safety. Compounding pharmacies can still supply it with a prescription.

How is Sermorelin usually taken?

The commonly reported pattern is under the skin at bedtime, nightly, for months. That describes reported practice from trials and the community. It is not a recommendation for anyone, and several of these compounds interact with common medications.

How strong is the evidence for Sermorelin?

Grade A / B on this site's A-to-D scale. A means approved as a medicine somewhere, with large controlled trials behind that use. The one with a prescription route. Weakest per dose.

Is Sermorelin banned in drug-tested sport?

Yes. Sermorelin is on the World Anti-Doping Agency prohibited list. Anyone who competes in a sport with drug testing, from college athletics to fitness competitions, can fail a test for it.

How long does Sermorelin stay in the body?

The half-life, the time for half a dose to leave the body, is about ~10–20 minutes. A short half-life means it wears off fast and is taken more often; a long one means once a week can be enough. Stored as a dry powder it keeps for months in the fridge; once mixed with water it is used within a few weeks.

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Go deeper on Sermorelin in The Peptide Course
How people commonly use it, what they notice, side effects, who stays away, and how good the evidence really is. Plus how to buy a vial that is actually Sermorelin, and how to mix it. Six lessons are free.
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Research-use disclaimer — Sermorelin is referenced here for research education only. It is not approved by the FDA for human consumption, treatment, cure, or diagnosis of any condition. Nothing on this page is medical advice. Consult a licensed physician for anything related to your health.